Fluconazole and Itraconazole Resistance of Yeasts Isolated from the Bloodstream and Catheters of Hospitalized Pediatric Patients

GUSTAVO GIUSIANO; MAGDALENA MANGIATERRA; VIVIANA GARCIA SAITO; FLORENCIA ROJAS; VERÓNICA GÓMEZ; MARÍA CRISTINA DÍAZ

CHEMOTHERAPY

KARGER

Lugar: Basilea - Suiza; Año: 2006 p. 254 - 259

0009-3157

Background: In critically ill children, Candida species and other yeasts appear as an important nosocomial pathogen. The emerging fungal pathogens are usually less susceptible to azole compounds, and the management of such infections could be problematic. Methods: 6,065 bloodstream cultures and 627 catheters from intensive care units and hospitalized oncology pediatric patients were studied. Antifungal susceptibility testing of isolates was performed according to the reference broth microdilution method described by the National Committee for Clinical Laboratory Standards (M27-A). Results: We found a low activity of fl uconazole (FCZ) and itraconazole (ITZ) against Candida glabrata , C. albicans , C. tropicalis and C. haemulonii . Resistant strains to FCZ and ITZ were detected. Conclusion: Results reveal the emergence of antifungal-resistant species and a change in the predominant role of C. albicans as a cause of candidemia in hospitalized children.