Terbinafine susceptibility patterns for onychomycosis-causative dermatophytes and Scopulariopsis brevicaulis

A.J. CARRILLO-MUÑOZ; G. GIUSIANO; C.D. CARDENES; J.M. HERNÁNDEZ MOLINA; E. ERASO; G. QUINDOS; C. GUARDIA; O. DEL VALLE; C. TUR-TUR; J. GUARRO

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

ELSEVIER SCIENCE BV

Año: 2008 p. 540 - 543

0924-8579

The in vitro antifungal activity of terbinafine against 521 clinical isolates of seven species of dermatophytes, including four onychomycosiscausative species, as well as five Scopulariopsis brevicaulis isolates was determined by a modified Clinical and Laboratory Standards Institute microdilution method. Results showed a high antifungal activity of terbinafine against all dermatophyte isolates (geometric minimal inhibitory concentration (MIC) = 0.026 g/mL; concentration inhibiting 50% of mycological growth (MIC50) = 0.03g/mL; and concentration inhibiting 90% of mycological growth (MIC90) = 0.06g/mL). The geometric mean MICs against onychomycosis-causative dermatophyte species was lower (0.024 g/mL) than the global MIC. However, the in vitro activity of terbinafine against S. brevicauliswas considerably lower (geometric mean MIC = 1.38 g/mL) in comparison with dermatophytes. The antifungal activity of itraconazole was lower than that of terbinafine against these fungi. These data confirm the high in vitro antifungal activity of terbinafine against dermatophytes, under standardised conditions.Scopulariopsis brevicaulis isolates was determined by a modified Clinical and Laboratory Standards Institute microdilution method. Results showed a high antifungal activity of terbinafine against all dermatophyte isolates (geometric minimal inhibitory concentration (MIC) = 0.026 g/mL; concentration inhibiting 50% of mycological growth (MIC50) = 0.03g/mL; and concentration inhibiting 90% of mycological growth (MIC90) = 0.06g/mL). The geometric mean MICs against onychomycosis-causative dermatophyte species was lower (0.024 g/mL) than the global MIC. However, the in vitro activity of terbinafine against S. brevicauliswas considerably lower (geometric mean MIC = 1.38 g/mL) in comparison with dermatophytes. The antifungal activity of itraconazole was lower than that of terbinafine against these fungi. These data confirm the high in vitro antifungal activity of terbinafine against dermatophytes, under standardised conditions.50) = 0.03g/mL; and concentration inhibiting 90% of mycological growth (MIC90) = 0.06g/mL). The geometric mean MICs against onychomycosis-causative dermatophyte species was lower (0.024 g/mL) than the global MIC. However, the in vitro activity of terbinafine against S. brevicauliswas considerably lower (geometric mean MIC = 1.38 g/mL) in comparison with dermatophytes. The antifungal activity of itraconazole was lower than that of terbinafine against these fungi. These data confirm the high in vitro antifungal activity of terbinafine against dermatophytes, under standardised conditions.90) = 0.06g/mL). The geometric mean MICs against onychomycosis-causative dermatophyte species was lower (0.024 g/mL) than the global MIC. However, the in vitro activity of terbinafine against S. brevicauliswas considerably lower (geometric mean MIC = 1.38 g/mL) in comparison with dermatophytes. The antifungal activity of itraconazole was lower than that of terbinafine against these fungi. These data confirm the high in vitro antifungal activity of terbinafine against dermatophytes, under standardised conditions.S. brevicauliswas considerably lower (geometric mean MIC = 1.38 g/mL) in comparison with dermatophytes. The antifungal activity of itraconazole was lower than that of terbinafine against these fungi. These data confirm the high in vitro antifungal activity of terbinafine against dermatophytes, under standardised conditions.