Chemical characterization and antifungal activity of Origanum vulgare , Thymus vulgaris essential oils and carvacrol against Malassezia furfur

VINCIGUERRA, VITTORIO; ROJAS, FLORENCIA; TEDESCO, VIVIANA; GIUSIANO, GUSTAVO; ANGIOLELLA, LETIZIA

NATURAL PRODUCT RESEARCH

TAYLOR & FRANCIS LTD

Año: 2018 p. 1 - 5

1478-6419

The composition of the essential oils (EOs) of O. vulgare L. EO andT. vulgaris EO, were analyzed by GC and GC?MS. Antifungal activitiesof the EOs and its main component, carvacrol, were evaluatedagainst 27 clinical isolates of Malassezia furfur. Minimum inhibitoryconcentrations (MICs) were measured according to the brothmicrodilution protocols by Clinical and Laboratory Standards Institute(CLSI) modified for Malassezia spp. EOs and carvacrol showed low MICvalues ranged 450?900 μg/ml against M. furfur. No differences in EOsantifungal activity were observed in sensitive to resistant fluconazoleisolates. The antifungal activity obtained showed O. vulgare EO,T. vulgaris EO and carvacrol, their compound, as potential antimicrobialagents against M. furfur, yeast associated with human mycoses.