Sertaconazole Nitrate Shows Fungicidal and Fungistatic Activity Against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, Causative Agents of Tinea Pedis.

CARRILLO MUÑOZ AJ; TUR-TUR C; CARDENES CD; ESTIVILL MD; GIUSIANO G

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

AMER SOC MICROBIOLOGY

Lugar: Washington; Año: 2011 vol. 55 p. 4420 - 4421

0066-4804

The fungistatic and fungicidal activity of sertaconazole against dermatophytes was evaluated by testing 150 clinical isolates of causative agents of tinea pedis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activity of sertaconazole against these isolates were 0.26 and 2.26 μg/ml, respectively, though values were lower for T. mentagrophytes compared with the others. This is the first comprehensive demonstration of the fungicidal activity of sertaconazole against dermatophytes.