Utilidad del panel Sensititre YeastOne® para detectar especies de Candida resistentes a los antifúngicos

CÓRDOBA, SUSANA; ABIEGA, CLAUDIO; AGORIO, IRIS; AMIGOT, SUSANA; ARDIZZOLI, KARINA; GIUSIANO, GUSTAVO; GUELFAND, LILIANA; LÓPEZ MORAL, LAURA; MALDONADO, IVANA; PINEDA, GLORIA; GARCIA-EFFRON, GUILLERMO

REVISTA ARGENTINA DE MICROBIOLOGíA

ASOCIACION ARGENTINA MICROBIOLOGIA

Lugar: Buenos Aires; Año: 2022 vol. 54 p. 9 - 14

0325-7541

We evaluated the interlaboratory agreement, the essential agreement, and the categorical agreement between the Sensititre YeastOneTM panel and the reference methods M27 4thEdition of the Clinical and Laboratory Standards Institute (CLSI), and the EDef 7.3.1 of the European Committee on Antifungal Susceptibility Testing (EUCAST). We studied 67 Candida strainsisolated from different clinical samples and 9 Candida strains with resistance to fluconazole andechinocandins. The highest percentage of interlaboratory agreement was observed with amphotericin B (96.8%), and the lowest percentage with voriconazole (77.2%). Caspofungin showed 5.8% of very major errors when compared with the CLSI reference method. For EUCAST, itraconazole, posaconazole, and anidulafungin showed high percentages of major errors: 17.6%,18.1%, and 19.6%, respectively. Sensititre YeastOneTM is a reliable alternative, and easy toperform for detecting Candida species resistant to antifungal drugs, with some limitations forechinocandins. Results are comparable to those of the reference methods.© 2021 Asociacion´ Argentina de Microbiolog´ıa. Published by Elsevier Espana, ? S.L.U. This is anopen access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).