Natural speech algorithm applied to baseline interview data can predict which patients will respond to psilocybin for treatment-resistant depression

CARRILLO, FACUNDO; SIGMAN, MARIANO; FERNÁNDEZ SLEZAK, DIEGO; ASHTON, PHILIP; FITZGERALD, LILY; STROUD, JACK; NUTT, DAVID J.; CARHART-HARRIS, ROBIN L.

JOURNAL OF AFFECTIVE DISORDERS

ELSEVIER SCIENCE BV

Año: 2018 vol. 230 p. 84 - 86

0165-0327

Background: Natural speech analytics has seen some improvements over recent years, and this has opened a window for objective and quantitative diagnosis in psychiatry. Here, we used a machine learning algorithm applied to natural speech to ask whether language properties measured before psilocybin for treatment-resistant can predict for which patients it will be effective and for which it will not. Methods: A baseline autobiographical memory interview was conducted and transcribed. Patients with treatment-resistant depression received 2 doses of psilocybin, 10 mg and 25 mg, 7 days apart. Psychological support was provided before, during and after all dosing sessions. Quantitative speech measures were applied to the interview data from 17 patients and 18 untreated age-matched healthy control subjects. A machine learning algorithm was used to classify between controls and patients and predict treatment response. Results: Speech analytics and machine learning successfully differentiated depressed patients from healthy controls and identified treatment responders from non-responders with a significant level of 85% of accuracy (75% precision). Conclusions: Automatic natural language analysis was used to predict effective response to treatment with psilocybin, suggesting that these tools offer a highly cost-effective facility for screening individuals for treatment suitability and sensitivity. Limitations: The sample size was small and replication is required to strengthen inferences on these results.