INVESTIGADORES
PEREZ LLORET Santiago
capítulos de libros
Título:
Drug-Induced Movement Disorders in Elderly Patients
Autor/es:
SANTIAGO PEREZ LLORET; JEAN-LOUIS MONTASTRUC; OLIVIER RASCOL
Libro:
Movement Disorders in Dementia
Editorial:
Springer
Referencias:
Año: 2013; p. 200 - 231
Resumen:
Movement disorders such as dystonia, akathisia, parkinsonism, chorea,
stereotypies, myoclonus, or tics can be observed during exposure to
a large number of drugs commonly used for the treatment of diverse
medical conditions. The most frequent drugs connected to movement
disorders are antipsychotics, but they can also be observed with a
variety of drugs, such as metoclopramide, prochlorperazine, cinnarizine,
flunarizine, H1 antihistaminergic drugs, trimetazidine, or serotonin
reuptake inhibitors. Clinical observation is crucial for differential
diagnosis of drug-induced movement disorders. Neuroimaging by
positron emission tomography (PET) or single photon emission
computed tomography (SPECT) may be of help for diagnosing druginduced
parkinsonism or tardive dyskinesia. The first therapeutic
measure is to withdraw the offending drug when possible. When
needed, muscarine receptor blockers can be used to treat acute dystonia,
propranolol or alprazolam for akathisia, and reserpine or methyldopa for
life-threatening tardive syndromes.