INVESTIGADORES
PEREZ LLORET Santiago
artículos
Título:
Pramipexole extended-release (once-daily formulation) for the treatment of Parkinson's disease.
Autor/es:
SANTIAGO PEREZ-LLORET; OLIVIER RASCOL
Revista:
EXPERT OPINION ON PHARMACOTHERAPY
Editorial:
INFORMA HEALTHCARE
Referencias:
Año: 2010 vol. 11 p. 2221 - 2230
ISSN:
1465-6566
Resumen:
IMPORTANCE OF THE FIELD: Immediate-release
pramipexole (P-IR) is indicated three times daily for the symptomatic
treatment of early and advanced Parkinson's disease (PD). An
extended-release formulation of pramipexole (P-ER) has been developed to
allow a once-daily formulation and to provide more stable dopaminergic
stimulation.
AREAS COVERED IN THIS REVIEW: This
review summarizes clinical pharmacology and pharmacokinetics of P-ER
for the treatment of early and advanced PD. The advantages and
disadvantages of the strategies available at present for achieving
continuous dopaminergic stimulation in the treatment of PD are discussed
first. The pharmacological properties are then summarized. Finally, the
clinical pharmacology and pharmacokinetics of P-ER are described.
WHAT THE READER WILL GAIN: The
reader will gain knowledge of the development of P-ER, its current
place in the pharmacotherapy of PD, and future directions.
TAKE HOME MESSAGE: P-ER
has been shown to be efficacious in early and advanced PD and it has
the same clinical profile when administered once daily as P-IR
administered three times daily. An overnight switching of P-IR to
dose-equivalent P-ER is successful in 80% of patients with early PD.