INVESTIGADORES
PEREZ LLORET Santiago
artículos
Título:
Activity-rest rhythm abnormalities in Parkinson's disease patients are related to dopaminergic therapy.
Autor/es:
SANTIAGO PEREZ-LLORET; MALCO ROSSI; DANIEL P. CARDINALI; MARCELO MERELLO
Revista:
THE INTERNATIONAL JOURNAL OF NEUROSCIENCE.
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Año: 2010 vol. 120 p. 11 - 16
ISSN:
0020-7454
Resumen:
OBJECTIVES: To compare
going to bed, waking-up, and immobility onset and offset times in
Parkinson's disease (PD) patients receiving levodopa and/or dopamine
agonists (i.e., dopaminergic therapy or DT) with "de novo" patients and
healthy controls and to correlate these parameters with self-reported
sleep disturbances.
METHODS: Fifteen
"de novo" and 60 PD patients on DT were included in the study.
Twenty-three subjects without history of sleep complaints and similar
age and sex distributions as the PD patients served as controls. Going
to bed and waking-up times were registered in 7-day sleep logs.
Nocturnal immobility onset and offset times were measured using
actigraphy. Sleep disorders were assessed applying the PD sleep scale
(PDSS).
RESULTS: Patients
on DT showed earlier waking-up and immobility offset times (40 min)
compared with controls and "de novo" patients. Multivariable regression
analysis showed that DT but not Hoehn & Yahr score was a significant
and independent predictor of early awakening time (OR = 4.0, 95% CI =
1.15-14.13). Patients manifesting more frequent nighttime psychotic
symptoms and more frequent daytime somnolence showed earlier going to
bed and waking-up times.
CONCLUSIONS: Results
suggest that activity-rest rhythm alteration in PD may be a consequence
of DT but not of disease stage. Altered sleep cycles correlated with
diurnal somnolence and nocturnal psychosis.