One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool

POLITANO, FABRIZIO; GRAN-MAGANO, ANA K.; LEADBEATER, NICHOLAS E.

New London

Simposio; 3nd annual ACS-CVS (Connecticut Valley Section) Symposium on Applied Synthesis.; 2019

ACS-CVS

A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. Using a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification.