INVESTIGADORES
ARRIOLA BENITEZ Paula Constanza
congresos y reuniones científicas
Título:
Type 4 secretion system (T4SS) and the secreted protein BPE005 from Brucella abortus modulates hepatic stellate cells responses.
Autor/es:
ARRIOLA BENITEZ, P. CONSTANZA; PESCE VIGLIETTI, AYELÉN IVANA; SERANTES, DIEGO R; HERRMANN, CLAUDIA; VANZULLI, SILVIA; COMERCI, DIEGO J; GIAMBARTOLOMEI, GUILLERMO H; DELPINO, M. VICTORIA
Lugar:
Buenos Aires
Reunión:
Congreso; LXIII Reunión Anual Sociedad Argentina de Inmunología. IV Reunión de la Sociedad Lationoamericana de Inmunodeficiencias. II Congreso de Inmunología Franco-Argentino; 2015
Resumen:
The liver is affected in human brucellosis. Hepatic stellate cells (HSC) are the major cells involved in liver fibrosis, and they are the resident antigen-presenting cells. B. abortus (Ba) could be involved in the modulation of immune response in liver through activation of inflammasome with concomitant fibrosis to repair the damage. Ba tilts HSC to a profibrogenic phenotype in a way that involves a functional T4SS and the secreted protein BPE005. To determine in vivo relevance of the role of BPE005 in liver fibrosis, BALB/c mice were infected with Ba and bpe005 mutant. Masson´s trichrome (p
