ALTERATIONS ON A KEY NEPHROGENIC/CARDIOGENIC GENE EXPRESSION LINKED TO HYPERTENSION DEVELOPMENT

MAZZEI LUCIANA; SANZ, RAÚL LELIO; MANUCHA, WALTER

Clin Investig Arterioscler

Elsevier

Lugar: Barcelona; Año: 2019

0214-9168

The elevation of blood pressure produces specific organiclesions, including kidney and cardiac damage. On the other hand,cardiovascular disease usually leads to the development of hypertension.Thus, hypertension could be both a cause and a consequence ofcardiovascular disease. Previous studies linked the lack of nitric oxideto cardiovascular abnormalities, including hypertension,arteriosclerosis, myocardial infarction, cardiac hypertrophy, diastolicheart failure, and reduced endothelium-derived hyperpolarizing factorresponses, with shorter survival. The lack of this gas also leads torenal/cardiac abnormalities.It is widely known that nephrogenic deficiency is a risk factor forkidney disease. Besides, recent evidence suggests that alterations inWT-1, a key nephrogenic factor, could contribute to hypertensiondevelopment. Moreover, some genes involved in the development ofhypertension depend on WT-1.This knowledge makes essential to investigate and understand themechanisms regulating the expression of these genes during renal/cardiacdevelopment and hypertension. As a consequence, the most in-depthknowledge of the complex etiopathogenic mechanism responsible for thehypertensive disease will allow us to propose novel therapeutic tools.