Intranasal administration of a chlorpyrifos formulation in mice induces long-term changes in spatial memory, brain redox balance, and in the activity of enzymes belonging to the cholinergic and glutamatergic systems.

GALLEGOS, CRISTINA E.; GUMILAR, FERNANDA; BARTOS, MARIANA; TISERA, G; BAIER, CARLOS JAVIER

Exposición; The 2nd International Electronic Conference on Biomedicines; 2023

ecb2023.sciforum.net

The intranasal (IN) administration route represents a pathway for xenobiotics to reach the brain. The present report investigated the long-term consequences of IN administration of a chlorpyrifos formulation (fCPF) in mice. After an 8-month fCPF-free washout period, fur appearance and body injuries improved in the fCPF-treated group. Notably, spatial learning and memory enhancement was observed in the fCPF group. Changes in oxidative stress markers and the activities of enzymes from cholinergic and glutamatergic pathways were observed in specific brain areas from fCPF-treated mice. These disturbances, acting together, could be responsible for the described behavioral observations. Our results emphasize the IN-pathwayÂ’s importance in accessing xenobiotics to the brain