INVESTIGADORES
DOPAZO Hernan Javier
artículos
Título:
PupaSuite: Finding functional SNPs for large-scale genotyping purposes.
Autor/es:
CONDE L.; VAQUERIZAS J.M.; DOPAZO H.; ARBIZA L.; REUMERS J.; ROUSSEAU, F.; SCHYMKOWITZ, J.; DOPAZO, J.
Revista:
NUCLEIC ACIDS RESEARCH
Editorial:
OXFORD UNIV PRESS
Referencias:
Año: 2006 vol. 34 p. 621 - 625
ISSN:
0305-1048
Resumen:
We have developed a web tool, PupaSuite, for the selection of single nucleotide polymorphisms (SNPs) with potential phenotypic effect, specifically oriented to help in the design of large-scale geno- typing projects. PupaSuite uses a collection of data on SNPs from heterogeneous sources and a large number of pre-calculated predictions to offer a flexi- ble and intuitive interface for selecting an optimal set of SNPs. It improves the functionality of PupaSNP and PupasView programs and implements new facilities such as the analysis of users data to derive haplotypes with functional information. A new estimator of putative effect of polymorphisms has been included that uses evolutionary information. Also SNPeffect database predictions have been included. The PupaSuite web interface is accessible through http://pupasuite.bioinfo.cipf.es and through http://www.pupasnp.org.
