On-line preconcentration/determination of copper in parenteral solutions using activated carbon by inductively coupled plasma optical emission spectrometry

E.A. TAKARA; S.D. PASINI-CABELLO; S. CERUTTI; J.A. GÁSQUEZ; L.D. MARTINEZ

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

ELSEVIER

Lugar: Amsterdam ; Año: 2005 vol. 39 p. 735 - 739

0731-7085

Abstract A method for the on-line preconcentration of copper using a minicolumn packed with activated carbon and its subsequent determination by inductively coupled plasma optical emission spectrometry (ICP-OES) coupled with flow injection (FI) was studied. In order to determinate the copper concentration present in parenteral solutions; it was retained on activated carbon (AC) at pH 9.5. A sensitivity enrichment factor of 30- fold was obtained with respect to the copper determination by ICP-OES without preconcentration. The detection limit for the preconcentration of 25 ml of sample was 0.1g l−1. The precision for the ten replicate determinations at the 2.5 g l?1 Cu level was 3.0% relative standard deviation (R.S.D.), calculated with the peak heights. The calibration graph using the preconcentration method for cooper species was linear with a correlation coefficient of 0.9996 at levels near the detection limits up to at least 200 g l−1. The method was successfully applied to the determination of copper in parenteral solutions the determination of copper in parenteral solutions deviation (R.S.D.), calculated with the peak heights. The calibration graph using the preconcentration method for cooper species was linear with a correlation coefficient of 0.9996 at levels near the detection limits up to at least 200 g l−1. The method was successfully applied to the determination of copper in parenteral solutions.the determination of copper in parenteral solutions.