Immune mechanisms mediated by probiotic bacteria

GABRIELA PERDIGON; CAROLINA MALDONADO GALDEANO; LEMME DUMIT JOSÉ MARÍA; VELEZ EVA; SILVIA CAZORLA

Madrid

Simposio; International Symposium on Immunonutrition 2017 - 10th Anniversary; 2017

The gastrointestinal tract is an ecosystems containing microorganisms crucial for the maturation of the immune cells. Probioticmicroorganisms induce immune activation through: a) stimulation the epithelial cells (IEC), by adhesion or by their cell wall fragments b) activation of immune cells of the gut c) induce antimicrobial substances d) probiotic interaction with IEC, produce cytokines and chemokines to stimulate the Mucosal Immune System(MIS). We demonstrate: 1) Probiotic bacteria or their fragmentsinteract with the IEC, 2) this activation stimulate the MIS increasing the IgA cells in the intestine, bronchus and breast and inducinginmunomodulation through the cytokine IL10. 3) the IEC inducescytokines as IL6, MCP1 favoring the expansion of LB, the IgA+cells and infiltration of mononuclear cells as macrophages, toproduce IL10 and maintain homeostasis.4) The interaction withthe IEC, TLRs are involved, and CD206 (mannose receptor) inmacrophages and dendritic cells 5) probiotics do not induce inflammatory immune response, only produce a slight increase inthe immune cells of the lamina propria 6) The main immune response induced by probiotics is the Innate response; 7) There is notnegative effect by the prolonged consumption 8) probiotics in allergy induce Th1 balance with production of IgG not IgE; 9) theyinduce an increase in the functionality and microbicidal activity indistant cells from the gut as peritoneal and spleen macrophages