AGGRESSIVE BEHAVIOUR AND LOCOMOTOR ACTIVITY IN MALE SPRAGUE DAWLEY RATS WITH SEROTONINERGIC DEPLETION

MARIA BELEN MULLE BERNEDO; SEBASTIÁN GARCÍA MENÉNDEZ; RICARDO CABRERA

Mar del Plata

Congreso; LXI Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica; 2016

The serotoninergic system modulates appetitive, motivational and aggressive behaviours. The last one is particularly associ- ated ith territorial defence and the increase of aggressiveness. The reduction of HT synthesis by drug has proven effective in increasing aggressive behaviour, in strains and species prone toit, and locomotion activity. The aims ere to describe the aggres- sive behaviour induced by the tryptophanhydroxylase inhibition by parachlorophenylalanine pC A in a strain characterized by lo aggressiveness and to examine dose/day response on aggres- sive behaviour and locomotor activity. ale Sprague a ley rats days old ere used. The animals ere divided into groups na- ve, saline control and pC A treated rats mg/ g, i.p evaluated on the 3rd and 6th day after. e evaluated intermale aggression ith smaller males test and minutes before e tested locomotor activity.The aggressive behaviour as measured as the persecu- tion latency time L and presence of tromping, bites, attempted mounts and lateral threats (AB). We also measured non-social interaction freezing, lying, and sitting , social interaction snif ng and grooming and locomotor activity. The test as recorded and the videos analysed ith the inovea . . soft are. ata ere analysed by A A and and Tu ey s post Hoc test. e observed a signi cant decrease in L p . and a signi cant increase p . in non social interaction bet een the treated, control and na ve groups. There as a signi cant increase p . in A bet een the treated group tested on the rd and 6th day. There ere no signi cant differences in social interaction and locomotor activity.The depletion of HT affect L, A and non social exploration. A is related to the day/dose response even in a strain ith lo aggressiveness. Aggressive behaviour, as e describe, is related both to serotonergic depletion and to dose/ day response, hile there is no incidence in locomotion activity.