PROGESTERONE AND ESTROGEN PREVENTS THE APPEARANCE OF PREMOTOR AND MOTOR SIGNS IN MALE HEMIPARKINSONIAN RATS.

NATALIA BELÉN GONZALEZ; ANTONELLA ROSARIO RAMONA CÁCERES GIMENEZ; MARIA BELEN MULLE BERNEDO; SEBASTIÁN GARCÍA MENÉNDEZ; RIACARDO CABRERA

Mar del Plata

Congreso; LXI Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica; 2016

ar inson s disease is the second most prevalent neurodegen- erative disease after Alzheimer. A hydroxydopamine H A lesion simulates the motor de cits that occur due to a depletion of dopamine neurons in the nigrostriatal path ay, and has the advantage of presenting side biased motor impairment. Some reports concerning motor de cits indicate a favourable response to steroid administration in hemiparkinsonian animals. The objec- tive as to evaluate the neuroprotection of the neuroactivesteroids, progesterone and estrogen, over motor and pre-motor signs induced bya 6-OHDA lesion. Sprague-Dawley male rats (280 - 320g) 60 days old ere used. Hemipar insonism as induced by 6-OHDA stereotaxic lesion in left corpus striatum. The experimental groups ere Sham S , hemiparkinsonian H , and hemipar insonian treated subcutaneously ith estrogen and progesterone H E. Pre-motor signs ere evaluated by aforce swimming test and motor signs by Raturn. Data were analysed by ANOVA-1 and TuKey's post hoc. A significance decrease p