PERSONAL DE APOYO
GARCIA MENENDEZ Sebastian Marcelo Manuel
congresos y reuniones científicas
Título:
PREGNENOLONE INFUSED IN LATERAL SEPTUM IMPAIRS MEMORY ACQUISITION OF MALE RATS IN A PASSIVE AVOIDANCE TEST
Autor/es:
GARCÍA S; NANFARO F; CASAS S; CABRERA R; YUNES R
Lugar:
Huerta Grande - Cordoba
Reunión:
Congreso; II Reunión Conjunta de Neurociencias; 2010
Institución organizadora:
SOCIEDAD ARGENTINA DE NEUROCIENCIAS
Resumen:
Pregnenolone (Preg) and Preg-Sulfate (Preg-S) are neuroactive steroids (NS) that have a role as memory modulators, among other functions. Our objective was to study the effects of these NS in an aversive memory paradigm (step down passive avoidance test) when injected in the lateral septum nucleus (LSN) of male rats. Three groups were used: 1) Control; 2) Preg 12 μM); y 3) Preg-S 12 μM. After 24 hs. they were tested for retention. The administration of reagents (1μL) was done via a cannula implanted in the right LSN 30 minutes before training. Statistical analysis was performed using an ANOVA-1 test, adopting a value of p
