ROLE OF INNATE CD8+ T CELLS IN CANCER

CONSTANZA SAVID-FRONTERA; NATALIA SOLEDAD BAEZ; MARIA CECILIA RODRIGUEZ-GALAN

Buenos Aires

Congreso; JOINT MEETING OF BIOSCIENCE SOCIETIES; 2017

Innate CD8+ T cells were discovered about 10 years ago. Thesecells have particular phenotypic features (CD44hi CD122hi CD49dhi)and exert cytotoxic activity mainly through NKG2D expression withoutspecific antigen recognition. Innate CD8+ T cells express highlevels of the transcription factor Eomesodermin and low expressionof T-bet. They rapidly produce IFNg after IL-12 and IL-18 stimulationdue to constitutive expression of their receptors. Moreover, an antitumorrole of innate CD8+ cells has been recently postulated bothin mice and human. Our experiments using murine tumor cell linesdemonstrate that systemic expression of these 2 cytokines (by hydrodynamicinjection of their cDNAs) significantly attenuate tumorgrowth in WT mice compared to control group (injected with an emptycDNA) (p