Appearance of innate T cells in thymus in infectious/inflammatory conditions

BAEZ NATALIA SOLEDAD; CERBÁN FABIO; SAVID FRONTERA CONSTANZA ; RODRIGUEZ-GALÁN MARIA CECILIA

Buenos Aires

Congreso; LXIII Argentinean Immunology Society Meeting; 2015

Our previous work demonstrated that during the acute stage of certain infections (Trypanosoma cruzi or Candida albicans) with a strong Th1 component, there is an increase in CD8+CD44hi T cells in the thymus. Our flow cytometry data demonstrated that these cells express TCRCD122 and the transcription factor Eomesodermin but not Tbet. They produce high levels of IFN and proliferate in the presence of IL-15(p