Antiviral activity and physicochemical properties of 4-Amino-phenyl-quinazoline derivatives for Bovine Viral Diarrhea Virus (BVDV)

FERNANDEZ, GABRIELA ARACELI; FIDALGO, DANIELA M.; ROSAS, ROCÍO ; BATTINI, LEANDRO ; CASTRO, ELIANA ; CAVALLARO, LUCIA; BOLLINI, MARIELA

Congreso; The 23rd International Electronic Conference on Shynthetic Organic Chemistry; 2019

Bovine Viral Diarrhea Virus (BVDV) is a pestivirus whose infection in cattle is globallydistributed being endemic in many countries. We have identified potential molecules that dockinto the allosteric binding pocket of BVDV RdRp via structure-based virtual screening approach.Five of these compounds resulted active against BVDV in vitro. Among them,N-(2-morpholinoethyl)-2-phenylquinazolin-4-amine (EC50= 9.68±0.49 µM), was selected to performdifferent chemical modifications. Between twenty-seven derivatives, seven of them showedimproved antiviral activity. Compound 2-(4-(2-phenylquinazolin-4-yl)piperazin-1-yl)ethanolafforded the best values of antiviral activity and selectivity index (SI) and their physicochemicalproperties were examined in vitro, in terms of solubility and stability.