INVESTIGADORES
DIAZ Romina Gisel
congresos y reuniones científicas
Título:
Mineralocorticoid receptor activation is crucial in the signaling pathway to the Anrep effect.
Autor/es:
PÉREZ NG; CALDIZ CI; DÍAZ RG; ENNIS IL; CHIAPPE DE CINGOLANI G; CINGOLANI HE
Lugar:
Orlando
Reunión:
Congreso; Scientific Sessions of The American Heart Association; 2011
Institución organizadora:
The American Heart Association
Resumen:
Since reactive oxygen species (ROS) are critical mediators in the intracellular signaling leading to the Anrep effect or slow force response (SFR) to stretch, and the autocrine action of Angiotensin II (A2) released after stretch is the trigger for these ROS, experiments were performed to explore the role of A2 and its downstream targets on superoxide anion production (SOP). Rat cardiac slices were used to measure SOP by chemiluminescence (5 umol/L lucigenin). After 15 minutes of 1 nmol/L A2 SOP increased by 151±3 % of control (n=8, P
