Lactobacillus rhamnosus RC007with immune-modulatory properties in an experimental model of TNBS-induced colitis in mice.Potential use as a feed additive for pig production

GARCÍA G; DOGI, C. A.; DE MORENO DE LEBLANC A.; CAVAGLIERI, L.R.; GRECO C

Frontiers in Immunology

Office

Año: 2015

1663-4365

In piglets, the inflammatory processes that take place at intestinal level, are associatedwiththephysiologicalconsequencesproducedbyweaning, this induce significant changes that affect gut anatomy, theimmune function and consequently, the productivity indexes. In addition, an up-regulation of proinflammatory cytokines, mainly TNF was reported at weaning. Antibiotics have been banned as growth promoters in animal feed. Different alternatives, such as probiotics have been explored and represent a potentially significant therapeutic or preventive safe advance in animal production.In previousstudywefoundthat the lactic acid bacteria (LAB)L. rhamnosus RC007 isolated from maize silage was able to inhibit toxicogenic fungus and to improve silage fermentation in laboratory scale-silos, also proved to have no genes for resistance to antibiotics of veterinary medicine importance. The aim of this work was to evaluate the immunomodulatory effect of Lactobacillus rhamnosus RC007 in an experimental model of TNBS-induced colitis in mice. The trial was conducted to test the ability of LAB to attenuate the inflammatory effects that occur in the post weaning period and use it as a food additive in pig production.