Truncatones A-D, benzo[j]fluoranthenes from Annulohypoxylon species (Xylariaceae, Ascomycota)

SUDARMAN, ENGE; KUHNERT, ERIC; HYDE, KEVIN D.; SIR, ESTEBAN BENJAMIN; SURUP, FRANK; STADLER, MARC

TETRAHEDRON

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2016 vol. 72 p. 6450 - 6454

0040-4020

From stromata (fruiting bodies) of three xylariaceous fungi belonging to the genus Annulohypoxylon(A. leptascum, A. cf. truncatum and an unidentified Annulohypoxylon sp.), truncatone A (1), threeunprecedented derivatives named truncatones BeD (2e4) besides the known 4,5,40,50-tetrahydroxy-1,10-binaphthyl (BNT, 5), hypoxylonol C (6) and hypoxylonol F (7) were isolated. Planar structures of the newbenzo[j]fluoranthene derivatives 2e4 were determined on the basis of NMR and HRESIMS data. Whilethe relative configuration of 4 was demonstrated by ROESY NMR data and 1H,1H coupling constants,absolute configurations of 1, 2, 4 were determined by CD spectroscopy. Compounds 1, 3 and 4 exhibitedcytotoxicity against the mouse fibroblast cell line L929.