Disfunción cognitiva asociada a la patología parkinsoniana: el rol del hipocampo/ Cognitive impairment in Parkinson´s disease: the role of hippocampus

HERRERA, MACARENA; FALOMIR-LOCKHART, EUGENIA; DOLCETTI, FRANCO JUAN CRUZ; BELLINI, MARIA JOSE; HEREÑU, CLAUDIA B.

Revista Ciencia In Situ

Federación Argentina Científica de Estudiantes de Ciencias de la Salud

Lugar: CABA; Año: 2016 vol. 1

Parkinson?s disease is a neurodegenerative disorder that results from a progressive dopaminergic neuronal loss.It is considered a multifactorial condition due to the multiplicity of symptoms experienced by patients, which can begrouped by their disturbance in motor pathways and / or mesolímibics pathways. While this condition is known forits characteristic motor deficits, patients also have a wide variety of non-motor symptoms, such as impaired learningand memory, depression, gastrointestinal problems, among others, which severely affect their quality of life. Thesenon-motor symptoms result from dysfunction of interconnected systems, including the striatum, the neocortex andthe hippocampus and the different glutamatergic circuits involved in synaptic plasticity modulation. This review seeksto deepen the current knowledge regarding to cognitive impairment associated with parkinsonian pathology for abetter understanding of the neural changes at molecular, chemical and physiological level, mainly in the hippocampus.Knowledge of these mechanisms involved in non-motor PD could result in potential new therapeutic strategies