Actions of estrogens on glial cells: Implications for neuroprotection

AREVALO MA; SANTOS-GALINDO M; BELLINI MJ; AZCOITIA I; GARCIA-SEGURA LM

BIOCHIMICA AND BIOPHYSICA ACTA

Elsevier

Lugar: Amsterdam; Año: 2010 vol. 1800 p. 1106 - 1112

0006-3002

Glial cells are directly or indirectly affected by estradiol and by different estrogenic compounds, such as selective estrogen receptor modulators. Acting on oligodendrocytes, astrocytes and microglia, estrogens regulate remyelination, edema formation, extracellular glutamate levels and the inflammatory response after brain injury. In addition, estradiol induces the expression and release of growth factors by glial cells that promote neuronal survival. Therefore, glial cells are important players in the neuroprotective and reparative mechanisms of estrogenic compounds