INVESTIGADORES
BELLINI Maria Jose
artículos
Título:
Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors
Autor/es:
LÓPEZ RODRÍGUEZ AB; MATEOS VICENTE B; ROMERO-ZERBO SY; RODRIGUEZ-RODRIGUEZ N; BELLINI MJ; RODRIGUEZ DE FONSECA F; BERMUDEZ-SILVA FJ; AZCOITIA I; GARCIA-SEGURA LM; VIVEROS MP
Revista:
CEREBRAL CORTEX
Editorial:
OXFORD UNIV PRESS INC
Referencias:
Lugar: New York; Año: 2011
ISSN:
1047-3211
Resumen:
The neuroactive steroid estradiol reduces reactive astroglia after brain
injury by mechanisms similar to those involved in the regulation of
reactive gliosis by endocannabinoids. In this study, we have explored
whether cannabinoid receptors are involved in the effects of estradiol
on reactive astroglia. To test this hypothesis, the effects of
estradiol, the cannabinoid CB1 antagonist/inverse agonist AM251, and the
cannabinoid CB2 antagonist/inverse agonist AM630 were assessed in the
cerebral cortex of male rats after a stab wound brain injury. Estradiol
reduced the number of vimentin immunoreactive astrocytes and the number
of glial fibrillary acidic protein immunoreactive astrocytes in the
proximity of the wound. The effect of estradiol was significantly
inhibited by the administration of either CB1 or CB2 receptor
antagonists. The effect of estradiol may be in part mediated by
alterations in endocannabinoid signaling because the hormone increased
in the injured cerebral cortex the messenger RNA levels of CB2 receptors
and of some of the enzymes involved in the synthesis and metabolism of
endocannabinoids. These findings suggest that estradiol may decrease
reactive astroglia in the injured brain by regulating the activity of
the endocannabinoid system.