Dependent- and Independent-Endothelium Vasodilation in Children with Low Birth Weight and Its Relationship with Urinary Nitrites

PERAL DE BRUNO MARIA; LOPEZ ZIGARAN, S.; JOO TURONI CLAUDIO; ROSSANA CHAHLA; CHAILA ZULEMA; BAZÁN DE CASELLA C

Puerto Varas

Congreso; XXV Annual Meeting, SLEP; 2015

SLEP

Objective: To study, in children with low birth weight (LBW),urinary nitrites, and its relation with endothelial dependent (ED)-and independent (EID)-endothelium vasodilation.Methods: Children (4?6 years) with LBW (n = 20) or not (control:n = 11) were studied. Waist circumference, height, weight,blood pressure (BP), glucose, insulin, HOMA-IR, lipid profile andC reactive protein (uCRP) were determined. ED (reactive hyperaemia),EID (relaxation by topic nitroglycerin) and arterial stiffness(AS) were measured by pulse wave plethysmography. Nitricoxide bioavailability was determinate by urinary nitrites. Results: LBW showed decreased ED (control: 98 ± 33 vs. LBW:43 ± 9%; p < 0.04) with similar EID and AS respect to controls.Urinary nitrites and uCRP were significantly increased in LBW.No differences between anthropometric parameters and otherscardiometabolic risk markers were found. A positive correlationbetween urinary nitrites and uCRP was found only in LBW (Pearsonr = 0.78; 95% CI = 0.52?0.91; p < 0.001).Conclusions: The alterations in ED with similar values of EIDand AS indicate an earlier endothelial damage in children withLBW, which is accompanied by a proinflamatory state (uCRP increased).The fact that LBW presented an increased urinary nitritelevels and its correlation with uCRP indicates an compensatoryactivation of systemic nitric oxide bioavailability at this early stageof life.