Arterial Stiffness and Endothelial Function in Obese Children and Adolescents

PERAL DE BRUNO MARIA; NEGRETE, ALEJANDRO; JOO TURONI CLAUDIO; SALAS NICOLAS; BRUNO MARIA E.; BAZAN DE CASELLA C

Montevideo

Congreso; XXIII reunión anual de la Latin American Society of Pediatric Endocrinology; 2012

Latin American Society of Pediatric Endocrinology

Vascular function is impaired in hypertension, diabetes, metabolic syndrome (MS) and obesity. In the pediatric population there are few studies about the endothelial function (EF) and arterial stiffness (AS). Objective: To determine vascular function assessing EF and AS in obese children and adolescents and its relation to cardiovascular risk factors. Methods: We studied obese boys (BMI ≥ percentile of 97) of the endocrinology outpatient service of the Hospital del Niño Jesús (Hosp) with no history of prior disease (n=25, age: 12.6±0.5 years). We measured anthropometric parameters, fat mass (FM), blood pressure and laboratory data. The EF was assessed by reactive hyperemia and AS by the pulse wave. Data were compared with non-obese boys from the Hosp or Avellaneda school ? Monteros (n=13, 13.8±0.7 years). Results: The obese showed higher FM, waist circumference (WC), insulinemia and HOMA index. BMI was correlated with FM (R2: 0.5844, p