VASCULAR REACTIVITY IN HYPERTENSION BY CHRONIC NITRIC OXIDE DEFICIENCY: ROLE OF OXIDATIVE STRESS

MAMANI IRINA; CHABAN HASSAN; LLICAS SANTIAGO; NEGRETE, ALEJANDRO; MARAÑON RODRIGO; JOO TURONI CLAUDIO; PERAL DE BRUNO MARIA

Tucumán

Jornada; XXXJornadas Científicas de la Asociación de Biología de Tucumán; 2013

Asociación de Biología de Tucumán

In hypertension (HT), oxidative stress alters nitric oxide (NO) levels. Objective: To study in aortas isolated from rats with HT because of chronic deficiency of NO (L-NAME rats: RL) vascular reactivity (VR), nitrites levels and effect of oxidative stress. Methods: RL were treated with; tempol: RL-T or ascorbic acid: RL-VitC for 6 weeks. In isolated aortas basal tone (BT) was measured by sodium nitroprusside (SNP) response and VR was measured by noradrenaline (NA) and KCl response. Nitrites were measured by Griess reaction. Results were compared with control rats (CR) and CR treated with antioxidants.Results: RL showed HT (mean arterial pressure: MAP: 181±11, n=10 vs. CR: 110±2 mmHg, n=10, p