EVIDENCE FOR RESVERATROL MODULATING RAC1 ACTIVATION IN MICROGLIAL CELLS

TICCHI JULIA; WERTHEIMER, EVA; CORREA FERNANDO

Mar del Plata

Congreso; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2020

SAIC

Maternal immune activation (MIA) produces structural, metabolic, and epigenetic changes in the fetus resulting in long-term neurological and neuropsychiatric consequences. Microglial cells are one of the main effectors of the innate immune response in the CNS. Excessive microglial activation leads to CNS damage due to excessive production of pro-inflammatory mediators. It has been determined that Rac1 plays a central role in the inflammatory response and microglial neurotoxicity in the CNS.It has been demonstrated that resveratrol has anti-inflammatory, antioxidant properties that translate into neuroprotective effects in adults.