CELLULAR PHYSIOLOGICAL IMPROVEMENT BY SPINOCHROMES FROM SEA URCHIN EGGS. A POTENTIAL ALLY IN IMPROVING THE SECUELAES OF COVID-19

MARISA AVARO; TAMARA RUBILAR ; SILVINA MAIDANA; ALEJANDRA ROMERA; ELENA BARBIERI; AUGUSTO CRESPI-ABRIL; VALERIA BRICHETTI; JULIETA TEJADA; FERNANDO SALDARINI; GABRIELA DE LARRAÑAGA

Congreso; Reunión anual de sociedades de biociencias. SAIC.SAI.SAFIS.; 2022

Spinochromes are marine polyphenols known for their antioxidant properties, enhanceglutathione metabolism and reduce cellular inflammation. They are naturally concentrated inthe eggs of sea urchins and there are two therapeutic pharmacological formulationsmarketed in Russia and Germany. In Argentina, a nutraceutic with Echinochrome A (EchA)has been formulated as a product equivalent to that used in Russia and is being used in amulticenter clinical trial focused on patients with sequalae of COVID-19 (Long COVID-19),under the hypothesis of decreasing cellular inflammation and increasing cell viability. Patientrecruitment is closed, 54 patients have been recruited, with an average age of 51 years(60% women). The patients consume 6 ml of 0.025 mg/ml of EchA per day for 90 days andclinical, biochemical (biomarkers of inflammation and thrombosis) and psychologicalparameters are analyzed; all interconnected through a SKYMED telemedicine platform. Inparallel, EchA was evaluated to demonstrate cell viability activity in Madin Darby bovineKidney (MDBK) and Vero cells with neutral red in a concentration range of 0.0375 ug/ml to1000 ug/ml with exposure for 2 hours and 72 hours. Differences in cell viability were found incell type, exposure time and EchA concentration (p