Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients

CAMPRUBÍ, DANIEL; ALMUEDO-RIERA, ALEX; MARTÍ-SOLER, HELENA I.; SORIANO, ALEX; HURTADO, JUAN CARLOS; SUBIRÀ, CARME; GRAU-PUJOL, BERTA; KROLEWIECKI, ALEJANDRO; MUÑOZ, JOSE

PLOS ONE

PUBLIC LIBRARY SCIENCE

Año: 2020 vol. 15

1932-6203

Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not receiving ivermectin. No differences were found between groups. We recommend the evaluation of high-doses of ivermectin in randomized trials against SARS-CoV-2.