INVESTIGADORES
MASUH Hector Mario
artículos
Título:
Suppression of food intake on Triatoma infestans by N- substituted methyl maleamates
Autor/es:
GONZÁLEZ AUDINO, P.; MASUH, H; LICASTRO, S.A.; VASSENA, C.; PICOLLO, M.I AND ZERBA, E
Revista:
PESTICIDE SCIENCE
Editorial:
John Wiley & Sons, Ltd.
Referencias:
Lugar: London; Año: 1997 vol. 49 p. 339 - 343
ISSN:
0031-613X
Resumen:
A series of
methyl esters of N-substituted (Z) and (E) maleamic acids
were synthesized and their effect on food intake measured on fifth instar
nymphs of Triatoma infestans. Suppression of food intake was found only
for the (Z) isomers. The initial reaction rate of the synthesized
compounds with glutathione (GSH) was calculated from the reaction in vitro
of the (Z) isomers. No reaction was observed with the (E)
isomers. Good correlation between the
suppression of food intake, measured by its ED50 (effective dose
that inhibits feeding of the 50% of the population) and the initial reaction
rate with GSH and the hydrophobic parameter p, was found.
