The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Platelet Physiology

GRESELE, PAOLO; FALCINELLI, EMANUELA; BURY, LOREDANA; PECCI, ALESSANDRO; ALESSI, MARIE-CHRISTINE; BORHANY, MUNIRA; HELLER, PAULA G.; SANTORO, CRISTINA; CID, ANA ROSA; ORSINI, SARA; FONTANA, PIERRE; DE CANDIA, ERICA; PODDA, GIANMARCO; KANNAN, MEGANATHAN; JURK, KERSTIN; CASTAMAN, GIANCARLO; FALAISE, CÉLINE; GUGLIELMINI, GIUSEPPE; NORIS, PATRIZIA; ZANINETTI C.; TOSSETO A.; FIORE M.; ZUÑIGA P; MIYAZAKI K; DUPUIS, A.; HAYWARD C.; CASONATTO A.; GRANDONE E.; MAZZUCONI MG.; JAMES P.; FABRIS F.; HENSKENS Y; NAPOLITANO M.; CURNOW J.; GKALEA V.; FEDOR M.; LAMBERT MP; ZIEGER B.; BARCELLA L.; COSMI B.; GIORDANO P.; PERGANTOU H; MELAZZINI F.; ABID M.; GLEMBOTSKY AC.; FERRARA G.; RUXO A.; DECKMYN H.; FRELINGER A.; HARRISON P.; MEZZANO D. ; MUMFORD AD.; LORDKIPANIDZÉ M.

Journal of thrombosis and haemostasis : JTH

NLM (Medline)

Año: 2021 vol. 19 p. 1364 - 1371

BACKGROUND: The ISTH Bleeding Assessment Tool (ISTH-BAT) has been validated for clinical screening of suspected von Willebrand disease (VWD) and for bleeding prediction. Recently it has been validated for subjects with inherited platelet disorders (IPD) (BAT-VAL study). OBJECTIVES: To determine whether the ISTH-BAT bleeding score (BS) predicts subsequent bleeding events requiring treatment in IPD patients. METHODS: Patients with IPD, type 1 VWD (VWD-1) and age- and sex-matched healthy controls enrolled in the BAT-VAL study were prospectively followed-up for 2 years and bleeding episodes requiring treatment were recorded. RESULTS: Of the 1098 subjects initially enrolled, 955 were followed-up and 124 suffered hemorrhages during follow-up, 60% of whom had inherited platelet function disorders (IPFD). Total number of events was significantly higher in IPFD (n = 235) than VWD-1 (n = 52) or inherited thrombocytopenia (IT; n = 20). Events requiring transfusions were 66% in IPFD, 5.7% in VWD-1, and 3% in IT. Baseline BS was significantly higher in IPFD patients with a bleeding event at follow-up than in those without (p