Inhibition of Bioenergetic Metabolism by the Combination of Metformin and 2-Deoxyglucose Highly Decreases Viability of Feline Mammary Carcinoma cells

ARBE, MARÍA FLORENCIA; FONDELLO, CHIARA; AGNETTI, LUCRECIA; ALVAREZ, G; TELLADO, MATÍAS NICOLÁS; GLIKIN, GERARDO CLAUDIO; FINOCCHIARO, LILIANA MARÍA ELENA; VILLAVERDE, MARCELA SOLANGE

CORDOBA

Congreso; Reunion Anual SAIB 2016; 2016

Feline mammary carcinoma (FMC) is a highly aggressive pathology that has been proposed as an interesting model of breast cancer disease. Metabolism has been described as a hallmark of cancer cell. The aim of the present work was to investigate the effects and mechanism of the modulation of metabolism by metformin (MET, an oral anti-diabetic drug), 2-deoxyglucose (2DG, HK inhibitor) or a combination of both drugs, MET/2DG on two established FMC cells lines: AlRB (HER2 (3+) and Ki6715%). Treatments decreased both FMC cells viability in a concentration dependent manner (APH assay, p