INVESTIGADORES
SEPULVEDA Claudia Soledad
artículos
Título:
Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety
Autor/es:
BARRADAS, JS; ERREA, MI; SEPÚLVEDA CS; DAMONTE EB; D´ACCORSO NB
Revista:
JOURNAL OF HETEROCYCLIC CHEMISTRY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2014 vol. 51 p. 96 - 100
ISSN:
0022-152X
Resumen:
Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated.
