Impact of art on the restoration of Th17 and Treg subpopulations in blood and genital mucosal compartments during HIV infection

JULIANA FALIVENE; MARÍA PÍA HOLGADO; DIEGO HERNÁN ZURITA; NATALIA LAUFER; VALERIA FINK; CARINA L. CASTRO; MARÍA PAULA CARUSO; LUCAS E. OJEDA; YANINA GHIGLIONE; MARÍA JULIA RUIZ; PEDRO CAHN; OMAR SUED3 ; GABRIELA TURK; MARÍA MAGDALENA GHERARDI

Buenos Aires

Congreso; I Meeting LASID FAIC SAI; 2015

Th17 and Treg cells play a key role in HIV infection.Aim: to analyze the effect of antiretroviral therapy (ART) on theseT-cell subsets in peripheral blood and female genital mucosa(FGM) in different patient groups.Groups: HIVneg (n=24); HIV+ART+ (>5 years on ART, n=11);HIV+ARTnaïve (n=15). Samples: Peripheral blood: PBMCs;FGM: Cervical mononuclear cells (CMCs).PBMCs: %Th17 in HIV+ART+ was higher vs HIV+ARTnaive(p