Host genetic factors associated with symptomatic primary acute HIV infection and disease progression among Argentinean seroconverters.

ROMINA COLOCCINI; YANINA GHIGLIONE ; GABRIELA TURK; NATALIA LAUFER; MARÍA EUGENIA SOCIAS; OMAR SUED; PEDRO CAHN; HORACIO SALOMÓN; ANDREA MANGANO; MARÍA DE LOS ANGELES PANDO; GRUPO ARGENTINO DE SEROCONVERSIÓN.

Kuala Lumpur

Conferencia; 7th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 2013

International AIDS Society

Background Variants in HIV-coreceptor CCR5 and HLA genes are the most important host genetic factors associated with HIV infection and disease progression. Our aim was to analyze the association of these genetic factors in the presence of clinical symptoms during Primary HIV Infection (PHI) and disease progression within the first year post-infection. Methods Seventy patients diagnosed with HIV during acute/early PHI were studied (55 symptomatic and 15 asymptomatic). HIV progression was defined by presence of B or C events and/or CD4 T-cell count