Low emergence of nevirapine (NVP) and lamivudine (3TC) resistance after post-partum interruption of a triple drug regimen for prevention of HIV mother to child transmission (MTCT).

HECTOR PÉREZ; MOIRA VIGNOLES; NATALIA LAUFER; ALEJANDRO GÓMEZ; PATRICIA COLL; JORGE LATTNER; MARÍA JOSÉ ROLÓN; HORACIO SALOMÓN; PEDRO CAHN

Sydney, Australia

Conferencia; 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 2007

Objectives: Emergence of resistance to NVP may be a consequence of monotherapy to prevent HIV MTCT.Emergence of resistance to NVP may be a consequence of monotherapy to prevent HIV MTCT. Aim of study: to evaluate the emergence of resistant strains to NVP and 3TC after discontinuation of antiretroviral therapy (ART) with 3TC/zidovudine (ZDV)/NVP.to evaluate the emergence of resistant strains to NVP and 3TC after discontinuation of antiretroviral therapy (ART) with 3TC/zidovudine (ZDV)/NVP. Methods: Twenty pregnant women (ART naïve or pre-exposed only to ZDV) in whom 3TC/ZDV/NVP was prescribed for MTCT prophylaxis, were studied. They received ART for median of 4 months with median viral load (VL) at labor: