Host genetic factors associated with symptomatic primary HIV infection and disease progression among Argentinean seroconverters

ROMINA COLOCCINI; DARIO DILERNIA; YANINA GHIGLIONE; GABRIELA TURK; NATALIA LAUFER; ANDREA RUBIO; EUGENIA SOCIAS; M.INÉS FIGUEROA; OMAR SUED; PEDRO CAHN; HORACIO SALOMÓN; ANDREA MANGANO; MARÍA DE LOS ANGELES PANDO

PLOS ONE

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2014

1932-6203

BACKGROUND: Variants in HIV-coreceptor C-C chemokine receptor type 5 (CCR5) and Human leukocyte antigen (HLA) genes are the most important host genetic factors associated with HIV infection and disease progression. Our aim was to analyze the association of these genetic factors in the presence of clinical symptoms during Primary HIV Infection (PHI) and disease progression within the first year. METHODS: Seventy subjects diagnosed during PHI were studied (55 symptomatic and 15 asymptomatic). Viral load (VL) and CD4 T-cell count were evaluated. HIV progression was defined by presence of B or C events and/or CD4 T-cell counts