Low rate of emergence of nevirapine and lamivudine resistance after post-partum interruption of a triple-drug regimen

HÉCTOR PÉREZ; MOIRA VIGNOLES; NATALIA LAUFER; ALEJANDRO GÓMEZ; PATRICIA COLL; JORGE LATTNER; MARÍA JOSÉ ROLÓN; HORACIO SALOMÓN; PEDRO CAHN

ANTIVIRAL THERAPY.

INT MEDICAL PRESS LTD

Año: 2008 vol. 13 p. 135 - 139

1359-6535

Introduction: Emergence of nevirapine (NVP) resistance may be a consequence of its use in monotherapy to prevent HIV mother-to-child transmission (MTCT). The aim of this study was to evaluate the emergence of strains resistant to NVP and lamivudine (3TC) after discontinuation of antiretroviral therapy (ART) with 3TC/zidovudine (ZDV)/NVP. Methods: Twenty pregnant women (ART-naive or preexposed only to ZDV), to whom 3TC/ZDV/NVP was prescribed as MTCT prophylaxis, were studied. They received ART for a median of 4 months with median viral load (VL) at labour