Biooxidations in chiral synthesis

MIHOVILOVIC, MARKO D.;; BIANCHI, DARIO A.

Asymmetric Organic Synthesis with Enzymes

Wiley-VCH Verlag GmbH & Co. KGaA

Año: 2008; p. 229 - 274

A review on biooxidn. and its application in chiral synthesis, with emphasis on enantioselective transformations yielding chiral building blocks for subsequent elaboration. Several reaction types and functional group transformations are outlined, focusing on biocatalytic processes of major impact on enantioselective synthesis and chiral product prepn. The oxidns. of alcs. and amines are discussed, along with kinetic resoln. of primary and secondary alcs., deracemization of amines and secondary alcs., oxygenation of non-activated carbon centers, enzymic epoxidn., Baeyer-Villiger oxidns., regiodivergent biooxidns., heteroatom oxidns., aryl dihydroxylations, and halogenation reactions.