Trypanosoma cruzi: infectivity modulation of a clone after passages through different hosts

PÉREZ BRANDAN C; ANGEL M. PADILLA; PATRICIO DIOSQUE; BASOMBRIO MIGUEL ANGEL

EXPERIMENTAL PARASITOLOGY

Elsevier

Año: 2006 vol. 114 p. 89 - 93

0014-4894

Although Trypanosoma cruzi virulence can be modified through passages in vivo or long-term in vitro culture, the mechanisms involved are poorly understood. Here we report modifications in the infectivity of a T. cruzi clone after passages in different hosts without detectable changes in parasite genetic patterns. A clone was obtained from a T. cruzi IIe isolate and showed to be less virulent than the original isolate (p