Induction of the tolerogenic dendritic cells DC-10 into the decidua: the contribution of trophoblast cells.

A SCHAFIR, V HAUK, B LARA, L FERNÁNDEZ, J BLEJER, A GRASSI BASSINO, E GRASSO, C PÉREZ LEIRÓS, R RAMHORST AND S GORI.

Congreso; Reunión Anual Conjunta SAIC-SAI-SAFIS; 2022

Immunomodulation and tolerance induction are strictly required during pregnancy. A novel and distinctive subset of HLA-G+ tolerogenic dendritic cell, DC-10, was found increased in first-trimester decidua. Recently, we showed that decidualized cells can condition maternal monocytes to DC-10 profile during the pre-implantation period. Here we aimed to explore the potential contribution of DC-10 in first-trimester decidua and the impact of trophoblast cells in its induction. First, we performed an integrated bioinformatic analysis since public array-based data. We found 212 up-regulated genes in DC-10 relative to mature and immature DC (p