Immunomodulation of RANTES by endogenous progesterone contribute to semiallogeneic-fetal antigens tolerance

R. RAMHORST, G. GUTIERREZ, A. CORIGLIANO, A. JUNOVICH AND L. FAINBOIM.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Munksgaard

Lugar: Copenhagen; Año: 2007 vol. 57 p. 147 - 152

8755-8920

Problem: Several studies indicate that RANTES is able to down-regulate T-cell responses which suggests it might be relevant for fetal-tolerance induction. However, the role of RANTES in pregnancy had not been established. Here we investigate RANTES levels during pregnancy in an abortion murine model. Method of Study: RANTES levels were determined in sera and feto-placental units from high resorption rate CBA/J x DBA/2 pregnant females and compared to CBA/J x BALB/c normal pregnant mice. Nulliparous, primiparous and multiparous CBA/J and BALB/c females were also studied. Results: Nulliparous CBA/J females were quantitatively deficient in RANTES sera levels, whereas regnancies with male BALB/c or DBA/2 increased its production . However, feto-placental units from CBA/J females are higher producers of progesterone and RANTES. Conclusions: Taken together, these data suggest that RANTES beneficial effect on feto-maternal interface requires a modulation of optimal concentration range. We postulate that RANTES levels might be modulated by progesterone and exacerbated placental expression could be associated to high resorption rate.