GENOTOXIC EVALUATION OF HOT AQUEOUS EXTRACT OF Baccharis articulata BY MOUSE BONE MARROW MICRONUCLEUS ASSAY

TORRES CRISTINA VANESA; CARIDDI LAURA NOELIA; ESCOBAR FRANCO MATÍAS; SABINI MARÍA CAROLA; SABINI LILIANA INÉS; ZANON SILVIA MATILDE

San Miguel de Tucumán

Congreso; III REUNIÓN CONJUNTA DE SOCIEDADES DE BIOLOGÍA DE LA REPÚBLICA ARGENTINA; 2015

SOCIEDADES DE BIOLOGÍA CONJUNTAS

Baccharis articulata (Lam.) Pers., distributed globally, is particularly abundant in the hills of Córdoba (Argentina) and it is often used in regional folk medicin, especially in the treatment of digestive ailments due to its hepatoprotective, coleretic and colagogue action. The species is found in many herbal products of great human consumption. Several studies have demonstrated that different extracts of B. articulata present antiviral, antifungal, antioxidant and anti-inflammatory activities. However, few studies have evaluated the potentially cytogenotoxic effect of herbal products that ensure thir safe use. The aim of this study was to determine the cytogenotoxic ability of hot aqueous extract of Baccharis articulata (HAE) using a mouse bone marrow micronucleus test. No toxicity was detected in any extract-treated groups (polychromatic erythrocytes/ normochromatic erythrocytes). HAE, at doses of 500, 1000 and 2000 mg/Kg, did not producean increase in the incidence of micronucleated polychromatic erythrocytes in bone marrow with respect to the negative control (p