EFFECTS OF GRAPES DERIVATES IN THE HEART

DIEZ ER

Mendoza

Congreso; XXXIV Reunion cientifica Anual de la Sociedad de Biologia de Cuyo; 2016

Sociedad de Biología de Cuyo

Cardiovascular diseases (CVD) are a major cause of morbidity and mortality worldwide due to malignant arrhythmias and heart failure. Patients suffering from metabolic syndrome, a combination of hypertension, dyslipidemia and obesity, are in greater risk for CVD. Therefore, it is extremely important to develop preventive treatments for those exposed to risk factors to reduce the progression to CVD and/or to decrease the severity of acute events, particularly lethal arrhythmias. Grape-derived compounds like wine and more recently grape pomace are promising agents for CVD reduction. Among the potential cardioprotective candidates derived from grapes, resveratrol catechin, epicatechin and quercetin are the most promising ones. In addition,melatonin was recently included in the list of grape-derived protective agents. However, the effects of the by-products of grapes in animal models that resemble the exposure to risk factor are still scarce. The general assumption is that grape-derived products are a good source of antioxidants, free radicals scavengers with anti-inflammatory effects. However, other biological effects should explain its beneficial effects because other antioxidants with similar potency fail to demonstrate protection in clinical scenarios. We tested some grape related compound and some of them (dealcoholized wine, grape pomace, resveratrol and melatonin showed protection against arrhythmic complications? of metabolic syndromes in rat models of risk factors exposure with increased Arrhythmogenesis. Since Mendoza is wine producing area, our findings could contribute to adding value to graperelated products and serve as fundamental to use more of the constituents of grapes for human health.