Chitosan-based formulations intended as masks surface protective spray for prevention of coronavirus dissemination

VICTORIA BELÉN AYALA-PEÑA; MARIA JULIA MARTIN; FLORENCIA FAVATELA; JESSICA OTAROLA; PEDRO MORAN ; MARIA VENTURA; CLAUDIA GENTILI ; MARÍA FLORENCIA SALCEDO; ANDREA YAMILA MANSILLA; SANDRA PEREZ; GUILLERMINA DOLCINI; VERA ALVAREZ; VERÓNICA LASALLE

ChemistrySelect

Wiley-VCH

Lugar: Weinheim; Año: 2022

The extraordinary occurrence of COVID-19 by the fast expansion of viral infections has propelled particular interest in developing novel antiviral and virucidal agents to guarantee personal security. The main objective of this work is to propose novel formulations able to optimize the use of personal protection elements. In recent years, chitosan (CH) has attracted attention for being an interesting multifunctional, biodegradable, non-antigenic, non-toxic, and biocompatible natural polymer with antimicrobial properties. In this work, formulations based on a CH matrix containing silver, and Copper based nanoparticles have been developed. The novelty of this proposal is that almost liquid formulations have been reached, possessing verified properties to inhibit evolved virus such as herpes simplex type 1 (HSV-1) and bovine betacoronavirus 1 (BCoV-1), the latter belonging to the same family of the well-known the well-known SARS-COV-19. Besidesantibacterial bioactivity; as well as the ability of these formulations to be easily sprayed on various surfaces, including conventional face masks, have been verified and discussed. The results presented in this contribution provide strong evidence on CH films as an ideal biosafe surface-protective for several daily used materials including the conventional face masks.